| pubmed-article:17714846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0025462 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0002716 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C1527240 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C0053246 | lld:lifeskim |
| pubmed-article:17714846 | lifeskim:mentions | umls-concept:C2000410 | lld:lifeskim |
| pubmed-article:17714846 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17714846 | pubmed:dateCreated | 2007-9-3 | lld:pubmed |
| pubmed-article:17714846 | pubmed:abstractText | We have investigated the effect of KHG21834, a benzothiazole derivative, on the amyloid beta protein (Abeta)-induced cell death in rat pheochromocytoma (PC12) cells and rat cortical and mesencephalic neuron-glia cultures. KHG21834 attenuated the Abeta(25-35)-induced apoptotic death in PC12 cells determined by characteristic morphological alterations and positive in situ terminal end-labeling (TUNEL). In the cortical neuron-glia cultures, KHG21834 reduced the Abeta(25-35)-induced apoptosis determined by TUNEL staining. Immunocytochemical analysis and Western blot analysis of Abeta(25-35)-induced neurotoxicity in mesencephalic neuron-glia cultures with anti-tyrosine hydroxylase (TH) antibody showed that Abeta(25-35) decreased the expression of TH protein by 60% and KHG21834 significantly attenuated the Abeta(25-35)-induced reduction in the expression of TH. Moreover, KHG21834 attenuates Abeta(25-35)-induced toxicity concomitant with the reduction of activation of extracellular signal-regulated kinase (ERK)1/2 to a lesser extent. ERK1 was more sensitively affected than ERK2 in attenuation of Abeta(25-35)-induced phosphorylation by KHG21834. These results demonstrated that KHG21834 was capable of protecting neuronal cells from Abeta(25-35)-induced degeneration. | lld:pubmed |
| pubmed-article:17714846 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17714846 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17714846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17714846 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17714846 | pubmed:issn | 0300-483X | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:ChoiSoo... | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:KimEun-AEA | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:ChoSung-WooSW | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:KimTae UeTU | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:HuhJae-WanJW | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:YangSeung-JuS... | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:HahnHoh-GyuHG | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:ChoiMyung-Min... | lld:pubmed |
| pubmed-article:17714846 | pubmed:author | pubmed-author:NamKee DalKD | lld:pubmed |
| pubmed-article:17714846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17714846 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17714846 | pubmed:volume | 239 | lld:pubmed |
| pubmed-article:17714846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17714846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17714846 | pubmed:pagination | 156-66 | lld:pubmed |
| pubmed-article:17714846 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17714846 | pubmed:meshHeading | pubmed-meshheading:17714846... | lld:pubmed |
| pubmed-article:17714846 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17714846 | pubmed:articleTitle | Protective effect of benzothiazole derivative KHG21834 on amyloid beta-induced neurotoxicity in PC12 cells and cortical and mesencephalic neurons. | lld:pubmed |
| pubmed-article:17714846 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. | lld:pubmed |
| pubmed-article:17714846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17714846 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
