Source:http://linkedlifedata.com/resource/pubmed/id/17712175
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2007-11-20
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pubmed:abstractText |
The expression of endothelin-1 (ET-1), which has been proposed to have a potential autocrine/paracrine role, varies during the menstrual cycle, and therefore, ET-1 may be involved in the cyclic change of the human endometrium. However, neither the synthesis nor the degradation of ET-1 in the endometrium has been determined in detail. We investigated endothelin-converting enzyme-1 (ECE-1), which converts big-ET-1 to active ET-1, and neutral endopeptidase (NEP), which cleaves and inactivates ET-1 in human endometrium in vivo and in vitro. Western blot analysis demonstrated that the change in the expression of ECE-1 during the menstrual cycle differed from that of NEP in the endometrium. ECE-1 was expressed by endometrial epithelial cells, whereas NEP was predominantly expressed by stromal cells in vivo and in vitro. In conclusion, our results suggest that spacio-temporal expression of two endopeptidases, ECE-1 and NEP, involved in the synthesis and degradation of ET-1, might regulate ET-1 action in human endometrium.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1554
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1229-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17712175-Aspartic Acid Endopeptidases,
pubmed-meshheading:17712175-Endometrium,
pubmed-meshheading:17712175-Epithelial Cells,
pubmed-meshheading:17712175-Female,
pubmed-meshheading:17712175-Humans,
pubmed-meshheading:17712175-Menstrual Cycle,
pubmed-meshheading:17712175-Metalloendopeptidases,
pubmed-meshheading:17712175-Neprilysin,
pubmed-meshheading:17712175-Stromal Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Distribution of endothelin-converting enzyme-1 and neutral endopeptidase in human endometrium.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. akiwase@med.nagoya-u.ac.jp
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pubmed:publicationType |
Journal Article
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