rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
2007-9-21
|
pubmed:abstractText |
Meningococcal disease may present as sepsis, meningitis or a combination of both. Impaired fibrinolysis and massive elevation of the plasminogen activator inhibitor-1 (PAI-1) is a characteristic feature of meningococcal sepsis. We and others have reported an association between mortality and the functional 4G/5G promoter polymorphism of the PAI-1 gene in children with meningococcal sepsis.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1538-7933
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2049-54
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:17697137-Adolescent,
pubmed-meshheading:17697137-C-Reactive Protein,
pubmed-meshheading:17697137-Child,
pubmed-meshheading:17697137-Child, Preschool,
pubmed-meshheading:17697137-Disseminated Intravascular Coagulation,
pubmed-meshheading:17697137-Female,
pubmed-meshheading:17697137-Fibrinogen,
pubmed-meshheading:17697137-Genotype,
pubmed-meshheading:17697137-Humans,
pubmed-meshheading:17697137-Infant,
pubmed-meshheading:17697137-Infant, Newborn,
pubmed-meshheading:17697137-Male,
pubmed-meshheading:17697137-Meningococcal Infections,
pubmed-meshheading:17697137-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:17697137-Polymorphism, Genetic,
pubmed-meshheading:17697137-Promoter Regions, Genetic
|
pubmed:year |
2007
|
pubmed:articleTitle |
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia.
|
pubmed:affiliation |
Department of General Pediatrics, Medical University of Graz, Graz, Austria.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|