|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2007-9-20
|
|
pubmed:abstractText |
We identified a ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) gene, which encodes a deubiquitinating enzyme and is expressed in the vasculature, by functional screening of a human endothelial cell (EC) cDNA library. UCHL1 is expressed in neurons, and abnormalities in UCHL1 are responsible for inherited Parkinson's disease via its effects on the ubiquitin-proteasome system. Therefore, the goal of present study was to clarify the role of the UCHL1 gene in vascular remodeling by evaluating nuclear factor-kappaB (NF-kappaB) inactivation in ECs and vascular smooth muscle cells (VSMCs).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/UCH-L1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/UCHL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin Thiolesterase
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1524-4636
|
|
pubmed:author |
pubmed-author:BabaYoshichikaY,
pubmed-author:CuiTai-XingTX,
pubmed-author:HayashiHirokiH,
pubmed-author:IchikawaTomonagaT,
pubmed-author:KanedaYasufumiY,
pubmed-author:KatsuyaTomohiroT,
pubmed-author:KikuchiYasushiY,
pubmed-author:MorishitaRyuichiR,
pubmed-author:NakagamiHironoriH,
pubmed-author:NishikawaTomoyukiT,
pubmed-author:OgiharaToshioT,
pubmed-author:RakugiHiromiH,
pubmed-author:SaitoYukihiroY,
pubmed-author:TakamiYoichiY,
pubmed-author:YasudaOsamuO
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2184-90
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17690318-Animals,
pubmed-meshheading:17690318-Balloon Dilation,
pubmed-meshheading:17690318-Carotid Artery Injuries,
pubmed-meshheading:17690318-Carotid Stenosis,
pubmed-meshheading:17690318-Cells, Cultured,
pubmed-meshheading:17690318-Disease Models, Animal,
pubmed-meshheading:17690318-Endothelial Cells,
pubmed-meshheading:17690318-Humans,
pubmed-meshheading:17690318-I-kappa B Proteins,
pubmed-meshheading:17690318-Muscle, Smooth, Vascular,
pubmed-meshheading:17690318-Myocytes, Smooth Muscle,
pubmed-meshheading:17690318-NF-kappa B,
pubmed-meshheading:17690318-Nitric Oxide,
pubmed-meshheading:17690318-Nitric Oxide Synthase Type III,
pubmed-meshheading:17690318-Protein Processing, Post-Translational,
pubmed-meshheading:17690318-RNA, Messenger,
pubmed-meshheading:17690318-RNA, Small Interfering,
pubmed-meshheading:17690318-RNA Interference,
pubmed-meshheading:17690318-Rats,
pubmed-meshheading:17690318-Time Factors,
pubmed-meshheading:17690318-Transfection,
pubmed-meshheading:17690318-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17690318-Ubiquitin,
pubmed-meshheading:17690318-Ubiquitin Thiolesterase,
pubmed-meshheading:17690318-Up-Regulation
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
|
|
pubmed:affiliation |
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
