Linked Life Data

17647144

Source:http://linkedlifedata.com/resource/pubmed/id/17647144

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-7-24
pubmed:abstractText
MAP Kinase Phosphatase-1 (MKP-1) is a dual specific phosphatase selective for MAP kinases, and was believed to implicate in the development of cardiac hypertrophy. However, whether MKP-1 is involved in the pathogenesis of diabetic cardiomyopathy is still unknown. We employed streptozotocin (STZ)-induced diabetic Sprague-Dawley rats to study the alteration of the MKP-1 expressions in the left ventricular myocardium in diabetic and normal groups by immunohistochemistry and real-time quantitative reverse transcription-polymerase chain reaction. The weight, blood sugar and urine sugar were measured before and after model induction in both control and diabetic groups. Changes of heart ultrastructure were analyzed by using transmission electron microscopy. The data of weight, blood sugar and urine sugar indicated no significant difference between the two groups before animal model induction. Eight weeks after the induction of diabetes, the differences between the control and the diabetic groups in weight, blood sugar and urine sugar were significant ( P<0.01). When compared with control, diabetic myocardium ultrastructural changes included myofibrillar disarrangements, mitochondria disruption, and increase in nuclear membrane invaginations. A significant decrease of MKP-1 expression was observed in the diabetic rats' myocardium ( P<0.01). Our study provides experimental evidences that hyperglycemia could damage myocardial ultrastructure. Moreover, we provided first evidence that down-regulation of cardioprotective peptide MKP-1, the MAPK pathway negative regulator, in myocardium of streptozotocin-induced diabetic rats, which may contribute to the deterioration of cardiac function and lead to diabetic cardiomyopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0947-7349
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17647144-Animals, pubmed-meshheading:17647144-Blood Glucose, pubmed-meshheading:17647144-Body Weight, pubmed-meshheading:17647144-Cell Cycle Proteins, pubmed-meshheading:17647144-Diabetes Mellitus, Experimental, pubmed-meshheading:17647144-Dual Specificity Phosphatase 1, pubmed-meshheading:17647144-Female, pubmed-meshheading:17647144-Gene Expression Regulation, Enzymologic, pubmed-meshheading:17647144-Glycosuria, pubmed-meshheading:17647144-Heart, pubmed-meshheading:17647144-Immediate-Early Proteins, pubmed-meshheading:17647144-Myocardium, pubmed-meshheading:17647144-Myocytes, Cardiac, pubmed-meshheading:17647144-Phosphoprotein Phosphatases, pubmed-meshheading:17647144-Protein Phosphatase 1, pubmed-meshheading:17647144-Protein Tyrosine Phosphatases, pubmed-meshheading:17647144-RNA, Messenger, pubmed-meshheading:17647144-Rats, pubmed-meshheading:17647144-Rats, Sprague-Dawley
pubmed:year
2007
pubmed:articleTitle
Expression changes of mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium of streptozotocin-induced diabetic rats.
pubmed:affiliation
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't