17626436

Source:http://linkedlifedata.com/resource/pubmed/id/17626436

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005507, umls-concept:C0014406, umls-concept:C0024868, umls-concept:C0039635, umls-concept:C0370003, umls-concept:C0681842, umls-concept:C0876936, umls-concept:C1511726, umls-concept:C2347026
pubmed:issue	12
pubmed:dateCreated	2007-7-13
pubmed:abstractText	Remediation of hazardous waste sites requires efficient and cost-effective methods to assess the extent of contamination by toxic substances including dioxin-like chemicals. Traditionally, dioxin-like contamination has been assessed by gas chromatography/high-resolution mass spectrometry (GC/MS) analysis for specific polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl congeners. Toxic equivalency factors for these congeners are then used to estimate the overall dioxin toxic equivalency (TEQ) of complex mixtures found in samples. The XDS-CALUX bioassay estimates contamination by dioxin-like chemicals in a sample extract by measuring expression of a sensitive reporter gene in genetically engineered cells. The output of the XDS-CALUX assay is a CALUX-TEQ value, calibrated based on TCDD standards. Soil samples taken from a variety of hazardous waste sites were measured using the XDS-CALUX bioassay and GC/MS. TEQ and CALUX-TEQ from these methods were compared, and a mathematical model was developed describing the relationship between these two data sets: log(TEQ) = 0.654 x log(CALUX-TEQ) + 0.058-(log(CALUX-TEQ))2. Applying this equation to these samples showed that predicted and GC/MS measured TEQ values strongly correlate (R2 = 0.876) and that TEQ values predicted from CALUX-TEQ were on average nearly identical to the GC/MS-TEQ. The ability of XDS-CALUX bioassay data to predict GC/MS-derived TEQ data should make this procedure useful in risk assessment and management decisions.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/ES04699, http://linkedlifedata.com/resource/pubmed/grant/ES08372, http://linkedlifedata.com/resource/pubmed/grant/P42 ES004699-23S30013
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-10948276, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-11979591, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-12540743, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-12790202, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-12850102, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-15096657, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-15099731, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-15819233, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-16120753, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-16245802, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-16829543, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-18969542, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-2124811, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-2846558, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-3464941, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-3719049, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-675706, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-7598497, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-7698077, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-8037844, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-8310450, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-8538618, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-8812265, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-9508738, http://linkedlifedata.com/resource/pubmed/commentcorrection/17626436-9831538
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0213155
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Dioxins, http://linkedlifedata.com/resource/pubmed/chemical/Hazardous Waste, http://linkedlifedata.com/resource/pubmed/chemical/Soil Pollutants
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0013-936X
pubmed:author	pubmed-author:BrownDavid JDJ, pubmed-author:ChuAndrew CAC, pubmed-author:ChuMichael DMD, pubmed-author:ClarkGeorge CGC, pubmed-author:DenisonMichael SMS, pubmed-author:GordonJohn DJD, pubmed-author:HandaHiroshiH, pubmed-author:KayamaFujioF, pubmed-author:NakamuraMasafumiM, pubmed-author:OrelienJeanJ
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	41
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4354-60
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:17626436-Biological Assay, pubmed-meshheading:17626436-Dioxins, pubmed-meshheading:17626436-Environmental Monitoring, pubmed-meshheading:17626436-Gas Chromatography-Mass Spectrometry, pubmed-meshheading:17626436-Hazardous Waste, pubmed-meshheading:17626436-Models, Chemical, pubmed-meshheading:17626436-Risk Assessment, pubmed-meshheading:17626436-Soil Pollutants
pubmed:year	2007
pubmed:articleTitle	Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data.
pubmed:affiliation	Xenobiotic Detection Systems, 1601 East Geer Street, Suite S, Durham, North Carolina 27704, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, N.I.H., Extramural, Validation Studies