Sepsis is associated with the generation of oxygen free radicals and (lacking) decreased selenium plasma concentrations. High doses of sodium selenite might reduce inflammation by a direct pro-oxidative effect and may increase antioxidant cell capacities by selenium incorporation into selenoenzymes. We investigated the effects of a continuous administration of high doses of selenium in septic shock patients.
Service de Réanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6-8 rue Saint Fiacre, 77104 Meaux, France. xforceville@invivo.edu
