Linked Life Data

17613764

Source:http://linkedlifedata.com/resource/pubmed/id/17613764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-7-6
pubmed:abstractText
Mantle cell lymphoma is a clinically heterogeneous disease, where further elucidation of pathogenetic mechanisms and better prognostic information is required. We evaluated genetic aberrations by interphase FISH on tissue sections or cytological material in 38 samples from 30 MCL patients, including 5 cases with cyclin D1 3'UTR low, which previously has been associated to unfavourable prognosis. The findings have been related to proliferation and clinical outcome. All but one of MCL showed t(11:14) translocation and in 22/30 samples taken at diagnosis or first relapse, one or several cytogenetic changes were detected; 11 deletions of ATM, 13 p53 deletions, 8 numerical c-myc-aberrations and 6 delp16. All but one MCL with low cyclin D1 3'UTR had additional cytogenetic changes, however no particular genetic change was strictly associated with this MCL variant. One fourth of MCL had none of the investigated additional aberrations and these tumours were in general less proliferative and some of these patients had a very long survival.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1042-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1344-52
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:17613764-Adult, pubmed-meshheading:17613764-Aged, pubmed-meshheading:17613764-Cell Cycle Proteins, pubmed-meshheading:17613764-Cell Proliferation, pubmed-meshheading:17613764-Cyclin D1, pubmed-meshheading:17613764-Cytogenetic Analysis, pubmed-meshheading:17613764-DNA-Binding Proteins, pubmed-meshheading:17613764-Female, pubmed-meshheading:17613764-Humans, pubmed-meshheading:17613764-In Situ Hybridization, Fluorescence, pubmed-meshheading:17613764-Interphase, pubmed-meshheading:17613764-Lymphoma, Mantle-Cell, pubmed-meshheading:17613764-Male, pubmed-meshheading:17613764-Middle Aged, pubmed-meshheading:17613764-Mutation, pubmed-meshheading:17613764-Protein-Serine-Threonine Kinases, pubmed-meshheading:17613764-Proto-Oncogene Proteins c-myc, pubmed-meshheading:17613764-RNA, Messenger, pubmed-meshheading:17613764-Survival Rate, pubmed-meshheading:17613764-Translocation, Genetic, pubmed-meshheading:17613764-Tumor Suppressor Protein p53, pubmed-meshheading:17613764-Tumor Suppressor Proteins
pubmed:year
2007
pubmed:articleTitle
Characterization of genetic changes in MCL by interphase FISH on tissue sections.
pubmed:affiliation
Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden. brigitta.sander@ki.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't