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rdf:type |
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lifeskim:mentions |
umls-concept:C0001418,
umls-concept:C0004763,
umls-concept:C0005390,
umls-concept:C0014852,
umls-concept:C0030054,
umls-concept:C0205263,
umls-concept:C0205332,
umls-concept:C0522530,
umls-concept:C1314939,
umls-concept:C1565860,
umls-concept:C1704259,
umls-concept:C1705323,
umls-concept:C1705987,
umls-concept:C1710082
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pubmed:issue |
11
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|
pubmed:dateCreated |
2007-10-16
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|
pubmed:abstractText |
Bile reflux contributes to oesophageal injury and neoplasia. COX-2 is involved in both inflammation and carcinogenesis; however, the precise mechanisms by which bile acids promote COX-2 expression in the oesophagus are largely unknown. We analysed the molecular mechanisms that govern bile acid-mediated expression of COX-2 in Barrett's oesophagus and oesophageal adenocarcinoma (OA).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
|
pubmed:issn |
1468-3288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1512-21
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pubmed:dateRevised |
2010-11-2
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pubmed:meshHeading |
pubmed-meshheading:17604323-Adenocarcinoma,
pubmed-meshheading:17604323-Animals,
pubmed-meshheading:17604323-Barrett Esophagus,
pubmed-meshheading:17604323-Bile Acids and Salts,
pubmed-meshheading:17604323-CREB-Binding Protein,
pubmed-meshheading:17604323-Cell Communication,
pubmed-meshheading:17604323-Cell Transformation, Neoplastic,
pubmed-meshheading:17604323-Cyclooxygenase 2,
pubmed-meshheading:17604323-Esophageal Neoplasms,
pubmed-meshheading:17604323-Gastroesophageal Reflux,
pubmed-meshheading:17604323-Humans,
pubmed-meshheading:17604323-Immunohistochemistry,
pubmed-meshheading:17604323-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:17604323-Rats,
pubmed-meshheading:17604323-Rats, Sprague-Dawley,
pubmed-meshheading:17604323-Reactive Oxygen Species,
pubmed-meshheading:17604323-Tumor Cells, Cultured
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pubmed:year |
2007
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|
pubmed:articleTitle |
COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma.
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pubmed:affiliation |
Department of Gastrointestinal Medicine and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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