|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2007-7-31
|
|
pubmed:abstractText |
The etiology of stroke in children with sickle cell anemia (SCA) is complex and poorly understood. Growing evidence suggests that genetic factors beyond the sickle cell mutation influence stroke risk in SCA. We previously reported risk associations with polymorphisms in several proinflammatory genes in SCA children with ischemic stroke. The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1524-4628
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2241-6
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17600229-Adolescent,
pubmed-meshheading:17600229-Anemia, Sickle Cell,
pubmed-meshheading:17600229-Cerebral Arteries,
pubmed-meshheading:17600229-Child,
pubmed-meshheading:17600229-Child, Preschool,
pubmed-meshheading:17600229-DNA Mutational Analysis,
pubmed-meshheading:17600229-Female,
pubmed-meshheading:17600229-G-Protein-Coupled Receptor Kinase 3,
pubmed-meshheading:17600229-Genetic Markers,
pubmed-meshheading:17600229-Genetic Predisposition to Disease,
pubmed-meshheading:17600229-Genetic Testing,
pubmed-meshheading:17600229-Genotype,
pubmed-meshheading:17600229-Humans,
pubmed-meshheading:17600229-Infant,
pubmed-meshheading:17600229-Interleukin-4 Receptor alpha Subunit,
pubmed-meshheading:17600229-Magnetic Resonance Angiography,
pubmed-meshheading:17600229-Magnetic Resonance Imaging,
pubmed-meshheading:17600229-Male,
pubmed-meshheading:17600229-Polymorphism, Genetic,
pubmed-meshheading:17600229-Promoter Regions, Genetic,
pubmed-meshheading:17600229-Risk Factors,
pubmed-meshheading:17600229-Stroke,
pubmed-meshheading:17600229-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17600229-beta-Adrenergic Receptor Kinases
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia.
|
|
pubmed:affiliation |
Department of Hematology/Oncology, Children's Hospital & Research Center Oakland, Oakland, CA 94609, USA. choppe@mail.cho.org
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
