|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003402,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0023810,
umls-concept:C0040048,
umls-concept:C0175697,
umls-concept:C0205263,
umls-concept:C0205314,
umls-concept:C0456387,
umls-concept:C0679622,
umls-concept:C0752312,
umls-concept:C1417014,
umls-concept:C1879547,
umls-concept:C2697656
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2007-7-19
|
|
pubmed:abstractText |
Oxidative stress contributes to the pathogenesis of many diseases, including atherosclerosis and sepsis. We have previously described a novel class of therapeutic compounds with antioxidant and antiinflammatory properties. However, at present, the intracellular targets of these compounds have not been identified. The purpose of this study was to elucidate the mechanism by which 2 structurally-related antioxidants (AGI-1067 and AGI-1095) inhibit LPS induction of tissue factor (TF) expression in human monocytic cells and endothelial cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1524-4636
|
|
pubmed:author |
pubmed-author:ChenXilinX,
pubmed-author:HolscherToddT,
pubmed-author:KunschCharlesC,
pubmed-author:LuchoomunJayrazJ,
pubmed-author:LuyendykJames PJP,
pubmed-author:MackmanNigelN,
pubmed-author:PiperJ DanielJD,
pubmed-author:ReddyK VeeraKV,
pubmed-author:TencatiMichaelM,
pubmed-author:WebbS LSL,
pubmed-author:ZhangRongR
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1857-63
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17561491-Antioxidants,
pubmed-meshheading:17561491-Blotting, Northern,
pubmed-meshheading:17561491-Blotting, Western,
pubmed-meshheading:17561491-Cell Communication,
pubmed-meshheading:17561491-Cells, Cultured,
pubmed-meshheading:17561491-Endothelial Cells,
pubmed-meshheading:17561491-Enzyme Activation,
pubmed-meshheading:17561491-Gene Expression Regulation,
pubmed-meshheading:17561491-Humans,
pubmed-meshheading:17561491-Lipopolysaccharides,
pubmed-meshheading:17561491-MAP Kinase Kinase Kinase 5,
pubmed-meshheading:17561491-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:17561491-Monocytes,
pubmed-meshheading:17561491-Oxidative Stress,
pubmed-meshheading:17561491-Probability,
pubmed-meshheading:17561491-RNA, Messenger,
pubmed-meshheading:17561491-Sensitivity and Specificity,
pubmed-meshheading:17561491-Signal Transduction,
pubmed-meshheading:17561491-Thromboplastin
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases.
|
|
pubmed:affiliation |
Department of Immunology, e Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
