Source:http://linkedlifedata.com/resource/pubmed/id/17556377
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2007-7-13
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| pubmed:abstractText |
Choriocarcinoma is a highly malignant tumor that can arise from trophoblasts of any type of gestational event but most often from complete hydatidiform mole. IGF-II plays a fundamental role in placental development and may play a role in gestational trophoblastic diseases. Several studies have shown that IGF-II is expressed at high levels in hydatidiform moles and choriocarcinoma tissues; however, conflicting data exist on how IGF-II regulates the behaviour of choriocarcinoma cells. The purpose of this study was to determine the contribution of the receptors for IGF-I and insulin to the actions of IGF-II on the regulation of choriocarcinoma cells metastasis. An Immuno Radio Metric Assay was used to analyse the circulating and tissue levels of IGF-I and IGF-II in 24 cases of hydatidiform mole, two cases of choriocarcinoma and eight cases of spontaneous abortion at the same gestational age. The JEG-3 choriocarcinoma cell line was used to investigate the role of IGF-II in the regulation of cell invasion. We found that mole and choriocarcinoma tissue express high levels of IGF-II compared to first trimester placenta. Both IGF-I and IGF-II regulate choriocarcinoma cell invasion in a dose dependent manner but through a different mechanism. IGF-II effects involve the activation of the InsR while IGF-I uses the IGF-IR. The positive effects of IGF-II on invasion are the result of enhanced cell adhesion and chemotaxis (specifically towards collagen IV). The actions of IGF-II but not those of IGF-I were sensitive to inhibition by the insulin receptor inhibitor HNMPA(AM)3. Our results demonstrate that the insulin receptor regulates choriocarcinoma cell invasion.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/INSR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxy-2-naphthalenyl-methyl...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1360-9947
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
567-76
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:17556377-Adult,
pubmed-meshheading:17556377-Antigens, CD,
pubmed-meshheading:17556377-Cell Adhesion,
pubmed-meshheading:17556377-Cell Line, Tumor,
pubmed-meshheading:17556377-Cell Movement,
pubmed-meshheading:17556377-Choriocarcinoma,
pubmed-meshheading:17556377-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:17556377-Female,
pubmed-meshheading:17556377-Humans,
pubmed-meshheading:17556377-Insulin-Like Growth Factor I,
pubmed-meshheading:17556377-Insulin-Like Growth Factor II,
pubmed-meshheading:17556377-Naphthalenes,
pubmed-meshheading:17556377-Phosphonic Acids,
pubmed-meshheading:17556377-Pregnancy,
pubmed-meshheading:17556377-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17556377-Receptor, IGF Type 1,
pubmed-meshheading:17556377-Receptor, Insulin,
pubmed-meshheading:17556377-Uterine Neoplasms
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| pubmed:year |
2007
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| pubmed:articleTitle |
IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor.
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| pubmed:affiliation |
Hormone Laboratory, Department of Chemistry, Universidad Nacional de Colombia, Bogotá, Colombia.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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