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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-9-3
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pubmed:abstractText |
Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated significantly less injury than their normal counterparts following the formation of IgG-containing immune complexes in the alveolar wall or in the wall of the peritoneum. Likewise, mice lacking MMP-3 demonstrated less lung injury following intra-tracheal instillation of the chemotactic cytokine macrophage inhibitory protein-2 (MIP-2) than did mice with MMP-3. There was a relationship between tissue injury (evidenced histologically) and accumulation of anti-laminin 111 immunoreactive material in the bronchoalveolar lavage (BAL) or peritoneal lavage (PL) fluid. There was also a relationship between tissue injury and influx of neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an important role for MMP-3 in acute inflammatory tissue injury.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10092827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10340950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10359808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10377203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10446891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10553093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10694567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-10919980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-11069839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-11320042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-11348456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-11533337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-11986332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-12006432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-12588713,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-1602740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-16564916,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-2757114,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17540368-9847290
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-4800
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-76
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:17540368-Acute Disease,
pubmed-meshheading:17540368-Animals,
pubmed-meshheading:17540368-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17540368-Chemokine CXCL2,
pubmed-meshheading:17540368-Chemokines,
pubmed-meshheading:17540368-Immunoglobulin G,
pubmed-meshheading:17540368-Inflammation,
pubmed-meshheading:17540368-Matrix Metalloproteinase 3,
pubmed-meshheading:17540368-Mice,
pubmed-meshheading:17540368-Mice, Knockout,
pubmed-meshheading:17540368-Neutrophils
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pubmed:year |
2007
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pubmed:articleTitle |
Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury.
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pubmed:affiliation |
Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road/Box 0602, Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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