Source:http://linkedlifedata.com/resource/pubmed/id/17518948
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-5-23
|
| pubmed:abstractText |
Schistosoma mansoni infection of mice increases the frequency of cells that are CD4+ CD25+ in the acute (4 and 8 weeks) and chronic (16 week) stages of infection. Depletion of > 85% of CD25+ cells in the acute or chronic stages of schistosome infection caused no overt changes in morbidity or immunological responses. The absence of effect in mice with CD25+ cells depleted may be due to the preferential expression of IL-4 and IL-10, two cytokines that are protective in schistosome infection, on CD25- CD4+ cells. We also assessed infection-induced changes of other regulatory markers, GITR, CD103 and CTLA-4 on CD4+ cells. We identified a marked expansion of CTLA-4+ population on CD25- CD4+ cells in acute and chronic infection. Blocking of CTLA-4 during acute, but not chronic infection, caused significant weight loss and altered the type 2 cytokine response of mice, with increased IL-4 and IL-5 production associated with significantly more Th2 cells and eosinophils in the liver granuloma. This study illustrates the complexity of regulation of T cells in schistosome infection and highlights a specific role for CTLA-4+, but not CD25+ cells, in the regulation of Th2 responses in helminth infection.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0141-9838
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
293-308
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:17518948-Animals,
pubmed-meshheading:17518948-Antigens, CD,
pubmed-meshheading:17518948-Antigens, Differentiation,
pubmed-meshheading:17518948-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17518948-CTLA-4 Antigen,
pubmed-meshheading:17518948-Cell Proliferation,
pubmed-meshheading:17518948-Cytokines,
pubmed-meshheading:17518948-Female,
pubmed-meshheading:17518948-Flow Cytometry,
pubmed-meshheading:17518948-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:17518948-Liver Cirrhosis,
pubmed-meshheading:17518948-Male,
pubmed-meshheading:17518948-Mice,
pubmed-meshheading:17518948-Mice, Inbred BALB C,
pubmed-meshheading:17518948-Schistosoma mansoni,
pubmed-meshheading:17518948-Schistosomiasis mansoni,
pubmed-meshheading:17518948-Specific Pathogen-Free Organisms,
pubmed-meshheading:17518948-Th2 Cells,
pubmed-meshheading:17518948-Up-Regulation
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice.
|
| pubmed:affiliation |
Institute of Molecular Medicine, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|