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rdf:type |
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lifeskim:mentions |
umls-concept:C0002345,
umls-concept:C0004083,
umls-concept:C0004096,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0023516,
umls-concept:C0030685,
umls-concept:C0030705,
umls-concept:C0044887,
umls-concept:C0185117,
umls-concept:C0205349,
umls-concept:C0389003,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-18
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pubmed:abstractText |
Cyclooxygenase-1 (COX-1) is a key enzyme involved in generation of prostanoids, important mediators and modulators of asthmatic inflammation. In a subpopulation of aspirin-sensitive asthmatics (ASA) inhibition of COX-1 by nonsteroidal anti-inflammatory drugs results in activation of inflammatory cells and development of symptoms. Alternatively spliced variants of COX-1 lacking 111 bp from exon 9 were described previously but have never been identified in human leucocytes peripheral blood leucocytes (PBL) or upper airway epithelial cells. We aimed to assess the expression of spliced variants of COX-1 mRNA in PBLs from patients with asthma and in healthy subjects (HS) referring the expression to patients characteristics (including ASA-sensitivity) and to aspirin-triggered 15-hydroxyeicosatetraenoic acid (15-HETE) generation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-hydroxy-5,8,11,13-eicosatetraenoi...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyeicosatetraenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0105-4538
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
628-34
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pubmed:meshHeading |
pubmed-meshheading:17508966-Adult,
pubmed-meshheading:17508966-Aged,
pubmed-meshheading:17508966-Alternative Splicing,
pubmed-meshheading:17508966-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17508966-Aspirin,
pubmed-meshheading:17508966-Asthma,
pubmed-meshheading:17508966-Cyclooxygenase 1,
pubmed-meshheading:17508966-Drug Hypersensitivity,
pubmed-meshheading:17508966-Female,
pubmed-meshheading:17508966-Gene Expression,
pubmed-meshheading:17508966-Humans,
pubmed-meshheading:17508966-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:17508966-Hypersensitivity,
pubmed-meshheading:17508966-Isoenzymes,
pubmed-meshheading:17508966-Leukocytes,
pubmed-meshheading:17508966-Male,
pubmed-meshheading:17508966-Middle Aged,
pubmed-meshheading:17508966-RNA, Messenger,
pubmed-meshheading:17508966-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17508966-Skin Tests
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pubmed:year |
2007
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pubmed:articleTitle |
Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release.
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pubmed:affiliation |
Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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