Source:http://linkedlifedata.com/resource/pubmed/id/17504241
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2007-9-10
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| pubmed:abstractText |
In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C>G and -403G>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n=176) or without (n=377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction ( approximately 50%) or angiographically confirmed CAD ( approximately 50%), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C>G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G>A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54-0.92], P=0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G>A genotype in controls (G/G: 44.7+/-3.3 ng/ml, G/A: 36.5+/-2.0 ng/ml, A/A: 28.7+/-2.5 ng/ml; P<0.001), non-diabetic CAD patients (G/G: 50.9+/-3.0 ng/ml, G/A: 42.2+/-2.6 ng/ml, A/A: 41.3+/-4.4 ng/ml; P<0.05) and diabetic CAD patients (G/G: 58.5+/-3.5 ng/ml, G/A: 49.6+/-4.1 ng/ml, A/A: 42.2+/-4.3 ng/ml; P<0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r=0.289, P<0.001) and platelet counts (r=0.253, P<0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
1470-8736
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
113
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
349-56
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17504241-Adult,
pubmed-meshheading:17504241-Aged,
pubmed-meshheading:17504241-Anthropometry,
pubmed-meshheading:17504241-Blood Pressure,
pubmed-meshheading:17504241-C-Reactive Protein,
pubmed-meshheading:17504241-Chemokine CCL5,
pubmed-meshheading:17504241-Coronary Artery Disease,
pubmed-meshheading:17504241-Diabetes Mellitus, Type 2,
pubmed-meshheading:17504241-Diabetic Angiopathies,
pubmed-meshheading:17504241-Gene Frequency,
pubmed-meshheading:17504241-Genotype,
pubmed-meshheading:17504241-Humans,
pubmed-meshheading:17504241-Lipids,
pubmed-meshheading:17504241-Male,
pubmed-meshheading:17504241-Middle Aged,
pubmed-meshheading:17504241-Myocardial Infarction,
pubmed-meshheading:17504241-Platelet Count,
pubmed-meshheading:17504241-Polymorphism, Single Nucleotide
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| pubmed:year |
2007
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| pubmed:articleTitle |
The RANTES -403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease.
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| pubmed:affiliation |
Cardiovascular Genome Center, Cardiovascular Hospital, Severance Hospital, Sinchon-dong, Seodaemun-gu, Seoul, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|