Linked Life Data

17499383

Source:http://linkedlifedata.com/resource/pubmed/id/17499383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-6-26
pubmed:abstractText
Evolution has generated enormous morphological diversity in animals and one of the genetic processes that might have contributed to this is evolution of the cis-regulatory sequences responsible for the temporal and spatial expression of genes regulating embryonic development. This could be particularly relevant to pleiotropic genes with multiple independently acting regulatory modules. Loss or gain of modules enables altered expression without loss of other functions. Here I focus on recent studies correlating differences in morphological traits between related species of Drosophila to changes in cis-regulatory sequences. They show that ancestral regulatory modules have evolved to mediate different transcriptional outputs and suggest that evolution of cis-regulatory sequences might reflect a general mechanism driving evolutionary change.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0168-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
350-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in Drosophila.
pubmed:affiliation
Department of Zoology, University of Cambridge, Cambridge, UK. pas49@cam.ac.uk
pubmed:publicationType
Journal Article, Review