Linked Life Data

17498684

Source:http://linkedlifedata.com/resource/pubmed/id/17498684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-6-11
pubmed:abstractText
The initiation of retinal development in Drosophila begins at the posterior center (PC) of the eye disc margin. The front of the differentiation wave, recognized as a morphogenetic furrow (MF), moves from posterior to anterior. What determines MF initiates from the specific PC site is still unclear. The unpaired (upd) gene is expressed at PC at early third instar, just before the time of MF initiation. Therefore, upd is expressed at the appropriate time and location for a specific role in defining the site of MF initiation. upd encodes a ligand for the Jak/STAT signaling pathway. In this report, we showed that the Upd/Jak/STAT signaling is required and sufficient to determine MF initiation. This is primarily achieved by repressing the transcription of wingless (wg), which is known to block MF initiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
306
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-71
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17498684-Animals, pubmed-meshheading:17498684-Animals, Genetically Modified, pubmed-meshheading:17498684-Cell Differentiation, pubmed-meshheading:17498684-Drosophila Proteins, pubmed-meshheading:17498684-Drosophila melanogaster, pubmed-meshheading:17498684-Gene Expression Regulation, Developmental, pubmed-meshheading:17498684-Immunohistochemistry, pubmed-meshheading:17498684-Janus Kinase 1, pubmed-meshheading:17498684-Ligands, pubmed-meshheading:17498684-Photoreceptor Cells, Invertebrate, pubmed-meshheading:17498684-Proto-Oncogene Proteins, pubmed-meshheading:17498684-STAT Transcription Factors, pubmed-meshheading:17498684-Signal Transduction, pubmed-meshheading:17498684-Transcription, Genetic, pubmed-meshheading:17498684-Transcription Factors, pubmed-meshheading:17498684-Wnt1 Protein
pubmed:year
2007
pubmed:articleTitle
Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development.
pubmed:affiliation
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't