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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
Recent evidence suggests that cholesterol metabolism participates in the pathogenesis of Alzheimer's disease. Apolipoprotein E is the main lipid carrier in the brain and the best-established risk factor for late-onset Alzheimer's disease. Intracellular cholesterol levels influence the generation of amyloid-beta peptides, the toxic species thought to be a primary cause of Alzheimer's disease. Finally, compounds that modulate cholesterol metabolism affect amyloid-beta generation. This review summarizes data linking apolipoprotein E and adenosine triphosphate-binding cassette transporters to aspects of cholesterol metabolism and Alzheimer's disease pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0957-9672
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17495608-ATP-Binding Cassette Transporters,
pubmed-meshheading:17495608-Alzheimer Disease,
pubmed-meshheading:17495608-Amyloid beta-Peptides,
pubmed-meshheading:17495608-Animals,
pubmed-meshheading:17495608-Apolipoproteins E,
pubmed-meshheading:17495608-Brain,
pubmed-meshheading:17495608-Cholesterol,
pubmed-meshheading:17495608-Homeostasis,
pubmed-meshheading:17495608-Humans,
pubmed-meshheading:17495608-Lipid Metabolism,
pubmed-meshheading:17495608-Lipids,
pubmed-meshheading:17495608-Mice,
pubmed-meshheading:17495608-Models, Biological
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pubmed:year |
2007
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|
pubmed:articleTitle |
Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Review
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