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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-5-30
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pubmed:abstractText |
Several investigators have coupled toxins to neuropeptides for the purpose of lesioning specific neurons in the central nervous system. By producing deficits in function these toxin conjugates have yielded valuable information about the role of these cells. In an effort to specifically stimulate cells rather than kill them we have conjugated the neuropeptide substance P to the catalytic subunit of cholera toxin (SP-CTA). This conjugate should be taken up selectively by neurokinin receptor expressing neurons resulting in enhanced adenylate cyclase activity and neuronal firing.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-10068170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-10395933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-10643883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-11106366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-11438603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-11900882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-12060713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-12113962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-12388616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-12402039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-12763083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-1321234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-14622833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-1659820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-1679515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-1691905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-2140898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-2174711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-2457531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-2858889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-3340425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-8385355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-8393861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-8769862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-8783505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-9259473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-9323204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-9572295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17493276-9654151
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2202
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17493276-Adenylate Cyclase,
pubmed-meshheading:17493276-Animals,
pubmed-meshheading:17493276-CHO Cells,
pubmed-meshheading:17493276-Cholera Toxin,
pubmed-meshheading:17493276-Cricetinae,
pubmed-meshheading:17493276-Cricetulus,
pubmed-meshheading:17493276-Dose-Response Relationship, Drug,
pubmed-meshheading:17493276-Drug Combinations,
pubmed-meshheading:17493276-Hyperalgesia,
pubmed-meshheading:17493276-Injections, Spinal,
pubmed-meshheading:17493276-Male,
pubmed-meshheading:17493276-Neurons, Afferent,
pubmed-meshheading:17493276-Nociceptors,
pubmed-meshheading:17493276-Rats,
pubmed-meshheading:17493276-Rats, Sprague-Dawley,
pubmed-meshheading:17493276-Receptors, Neurokinin-1,
pubmed-meshheading:17493276-Spinal Cord,
pubmed-meshheading:17493276-Substance P
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pubmed:year |
2007
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pubmed:articleTitle |
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
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pubmed:affiliation |
Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA. caudle@ufl.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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