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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-23
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pubmed:abstractText |
Beta-glucan was recently shown to have the ability to enhance and stimulate the immune system in humans, but little is known about its the anti-inflammatory effects. We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. beta-Glucan decreased the production and expression of TNF-alpha. In addition, it blocked LPS-stimulated activation of nuclear factor kappa B (NF-kappaB). Hence beta-glucan might suppress LPS-stimulated TNF-alpha production by inhibiting NF-kappaB in BV2 microglial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Formazans,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MTT formazan,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Glucans
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0916-8451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1360-4
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pubmed:meshHeading |
pubmed-meshheading:17485824-Animals,
pubmed-meshheading:17485824-Anti-Inflammatory Agents,
pubmed-meshheading:17485824-Cell Survival,
pubmed-meshheading:17485824-Cells, Cultured,
pubmed-meshheading:17485824-Dose-Response Relationship, Drug,
pubmed-meshheading:17485824-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17485824-Formazans,
pubmed-meshheading:17485824-Glucosides,
pubmed-meshheading:17485824-Lipopolysaccharides,
pubmed-meshheading:17485824-Mice,
pubmed-meshheading:17485824-Microglia,
pubmed-meshheading:17485824-Molecular Weight,
pubmed-meshheading:17485824-NF-kappa B,
pubmed-meshheading:17485824-RNA, Messenger,
pubmed-meshheading:17485824-Tetrazolium Salts,
pubmed-meshheading:17485824-Time Factors,
pubmed-meshheading:17485824-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17485824-beta-Glucans
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pubmed:year |
2007
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pubmed:articleTitle |
The suppressive effect of beta-glucan on the production of tumor necrosis factor-alpha in BV2 microglial cells.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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