rdf:type |
|
lifeskim:mentions |
umls-concept:C0029463,
umls-concept:C0032214,
umls-concept:C0035820,
umls-concept:C0049315,
umls-concept:C0205463,
umls-concept:C0243144,
umls-concept:C0332183,
umls-concept:C0370003,
umls-concept:C0600138,
umls-concept:C1384573,
umls-concept:C1514559,
umls-concept:C1710236,
umls-concept:C2347026,
umls-concept:C2936835
|
pubmed:issue |
9
|
pubmed:dateCreated |
2007-5-2
|
pubmed:abstractText |
Two major systems exist for folate cell entry: the reduced folate carrier (RFC) and the folate receptor (FR). Although defective RFC-mediated transport was frequently identified as a mechanism of methotrexate (MTX) resistance in osteosarcoma, the status of FR and its role in this disease are unknown.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-methyltetrahydrofolate,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Folate Receptors, GPI-Anchored,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolates
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1078-0432
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2557-67
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:17473184-Animals,
pubmed-meshheading:17473184-Antimetabolites, Antineoplastic,
pubmed-meshheading:17473184-Bone Neoplasms,
pubmed-meshheading:17473184-Carrier Proteins,
pubmed-meshheading:17473184-Cell Line, Tumor,
pubmed-meshheading:17473184-Drug Resistance, Neoplasm,
pubmed-meshheading:17473184-Folate Receptors, GPI-Anchored,
pubmed-meshheading:17473184-Folic Acid,
pubmed-meshheading:17473184-Folic Acid Antagonists,
pubmed-meshheading:17473184-Humans,
pubmed-meshheading:17473184-Methotrexate,
pubmed-meshheading:17473184-Osteosarcoma,
pubmed-meshheading:17473184-RNA, Messenger,
pubmed-meshheading:17473184-Receptors, Cell Surface,
pubmed-meshheading:17473184-Tetrahydrofolates,
pubmed-meshheading:17473184-Xenograft Model Antitumor Assays
|
pubmed:year |
2007
|
pubmed:articleTitle |
The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate.
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pubmed:affiliation |
Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, New York 10467, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|