Source:http://linkedlifedata.com/resource/pubmed/id/17471286
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-3-19
|
| pubmed:abstractText |
Tumor necrosis factor-alpha (TNF-alpha) is released from mast cells via an immunoglobulin E (IgE)-dependent mechanism. The variant G>A at -308 of TNFA is part of an extended haplotype HLA-A1-B8-DR3-DQ2 and influences the gene expression. We evaluated this variant in relation to IgE-mediated reactions to betalactams, in 427 subjects, including 167 cases and 260 age- and gender-paired controls. TNFA GG genotype was a significant independent predictor of the primary risk of betalactam allergy, concurrently with total IgE level, with an age- and sex-adjusted odds ratio estimated at 2.45 (95% confidence interval: 1.18-5.08, P=0.0163). Cases with -308AA genotype had a higher serum level of specific IgE than those with -308GA/GG genotype, with median levels (relative units) of 4.6 (inter-quartiles: 3.9-10.6) and 2.2 (1.4-4.3), respectively (P=0.0046). In conclusion, our results suggest an ambivalent influence of a genetic determinant of pro-inflammatory pathways on IgE-mediated hypersensitivity to betalactams.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1473-1150
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
8
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
162-8
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| pubmed:meshHeading |
pubmed-meshheading:17471286-Adult,
pubmed-meshheading:17471286-Anti-Bacterial Agents,
pubmed-meshheading:17471286-Case-Control Studies,
pubmed-meshheading:17471286-Drug Hypersensitivity,
pubmed-meshheading:17471286-Female,
pubmed-meshheading:17471286-Gene Frequency,
pubmed-meshheading:17471286-Genetic Predisposition to Disease,
pubmed-meshheading:17471286-Haplotypes,
pubmed-meshheading:17471286-Humans,
pubmed-meshheading:17471286-Immunoglobulin E,
pubmed-meshheading:17471286-Italy,
pubmed-meshheading:17471286-Male,
pubmed-meshheading:17471286-Middle Aged,
pubmed-meshheading:17471286-Odds Ratio,
pubmed-meshheading:17471286-Phenotype,
pubmed-meshheading:17471286-Polymorphism, Genetic,
pubmed-meshheading:17471286-Prospective Studies,
pubmed-meshheading:17471286-Risk Assessment,
pubmed-meshheading:17471286-Risk Factors,
pubmed-meshheading:17471286-Severity of Illness Index,
pubmed-meshheading:17471286-Skin Tests,
pubmed-meshheading:17471286-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17471286-beta-Lactams
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Association of tumor necrosis factor-alpha -308G>A polymorphism with IgE-mediated allergy to betalactams in an Italian population.
|
| pubmed:affiliation |
Inserm U-724, Faculté de Médecine, University of Nancy-Henri Poincaré and University Hospital Center (CHU) of Nancy, Nancy, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|