17466419

Source:http://linkedlifedata.com/resource/pubmed/id/17466419

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023767, umls-concept:C0027575, umls-concept:C0441655, umls-concept:C1522673
pubmed:issue	22
pubmed:dateCreated	2007-5-8
pubmed:abstractText	The adjuvant activity of Neisseria meningitidis serogroup B lipopoly(oligo)saccharide (LOS) from wild-type and genetically defined LOS mutants and unglycosylated meningococcal lipid A was assessed in C3H/HeN and C3H/HeJ mice. Meningococcal lipid A, a weak agonist for TLR4/MD-2 in human macrophages, was found to have adjuvant activity similar to that of wild-type and KDO(2)-lipid A LOS in C3H/HeN mice. All meningococcal LOS structures as adjuvants induced high titers of IgG1, IgG2a and IgG2b but very little IgG3 to OMP compared to no adjuvant PBS controls. In addition, induced OMP antibodies were shown to have high bactericidal activity against serogroup B meningococci. Purified LOS and lipid A structures failed to induce any adjuvant activity in C3H/HeJ mice indicating that meningococcal LOS as an adjuvant was TLR4-dependent. Unglycosylated meningococcal lipid A because of its weak agonist activity for human macrophages and retention of adjuvant activity may be a candidate for use in serogroup B meningococcal OMP and OMV vaccines and for use as an adjuvant in other vaccines.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 AI 033517, http://linkedlifedata.com/resource/pubmed/grant/R01 AI033517-14
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10067680, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10418898, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10438363, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10496868, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10558946, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10608079, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10627495, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10669351, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10727940, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-10837408, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11145680, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11301813, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11496013, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11553534, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11742971, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11777991, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11948150, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-11988262, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-12089673, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-12379680, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-12390352, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-12706694, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-12941142, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-13286429, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-14570885, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-14625548, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-14688118, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-14999615, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15051069, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15120002, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15186399, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15229469, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15550117, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15755593, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-15845500, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-16246469, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-16441441, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-2474611, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-6183224, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-7689627, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-8955282, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-9370256, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-9548250, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-9826376, http://linkedlifedata.com/resource/pubmed/commentcorrection/17466419-9887366
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8406899
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/Lipid A, http://linkedlifedata.com/resource/pubmed/chemical/Meningococcal Vaccines, http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0264-410X
pubmed:author	pubmed-author:SteeghsLianaL, pubmed-author:StephensDavid SDS, pubmed-author:ZughaierSusuS, pubmed-author:van der LeyPeterP
pubmed:issnType	Print
pubmed:day	30
pubmed:volume	25
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4401-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:17466419-Adjuvants, Immunologic, pubmed-meshheading:17466419-Animals, pubmed-meshheading:17466419-Antibodies, Bacterial, pubmed-meshheading:17466419-Humans, pubmed-meshheading:17466419-Immunoglobulin G, pubmed-meshheading:17466419-Lipid A, pubmed-meshheading:17466419-Macrophages, pubmed-meshheading:17466419-Meningococcal Infections, pubmed-meshheading:17466419-Meningococcal Vaccines, pubmed-meshheading:17466419-Mice, pubmed-meshheading:17466419-Mice, Inbred C3H, pubmed-meshheading:17466419-Neisseria meningitidis, pubmed-meshheading:17466419-Neisseria meningitidis, Serogroup B, pubmed-meshheading:17466419-Toll-Like Receptor 4
pubmed:year	2007
pubmed:articleTitle	TLR4-dependent adjuvant activity of Neisseria meningitidis lipid A.
pubmed:affiliation	Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 1440 Clifton Road NE, Atlanta, GA 30322, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural