Linked Life Data

17452843

Source:http://linkedlifedata.com/resource/pubmed/id/17452843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-24
pubmed:abstractText
V.A.C. Therapy applied to a cutaneous wound was hypothesized to alter vascular regulation in underlying tissue. Two full-thickness wounds were created on the dorsum of 7 New Zealand albino rabbits. One site was treated with V.A.C. Therapy; the other, with saline-moistened gauze. Local perfusion levels in the muscle were measured using laser Doppler flowmetry. Using vena caval occlusion, blood pressure was decreased progressively from baseline under vasonormal conditions and during systemic infusion of a vasodilator and a vasoconstrictor. The pressure-flow relationships for the carotid and V.A.C. Therapy-treated wound sites showed 3 distinct curves, with vasodilator curves shifted upwards and vasoconstrictor curves downwards relative to vasonormal curves (P < 0.05). By contrast, vasodilator curves in the saline-gauze treated sites were indistinguishable from vasonormal curves. Thus, in a rabbit model, application of V.A.C. Therapy to cutaneous wounds normalized the vascular response to vasoactive drugs in a manner similar to undisturbed carotid circulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0148-7043
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-60
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
V.A.C. Therapy normalizes vascular response of injured tissue in full-thickness wounds in rabbits.
pubmed:affiliation
Kinetic Concepts Inc., San Antonio, TX 78249, USA. kilpadid@kci1.com
pubmed:publicationType
Journal Article