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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-20
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pubmed:abstractText |
Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without priming with TNFalpha, suggesting that mPR3 expression on neutrophils is dependent on other priming events, such as isolation procedures . These priming events can be variable. Therefore, we analysed mPR3 expression on neutrophils before and after priming with TNFalpha to assess whether standardised assessment of mPR3 expression requires priming. Using neutrophils before and after priming with TNFalpha, we assessed percentages of mPR3(+) neutrophils in patients with AAV and in disease and healthy controls.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-4967
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1350-5
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pubmed:dateRevised |
2010-10-4
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pubmed:meshHeading |
pubmed-meshheading:17446240-Adult,
pubmed-meshheading:17446240-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:17446240-Arthritis, Rheumatoid,
pubmed-meshheading:17446240-Biological Markers,
pubmed-meshheading:17446240-Cell Membrane,
pubmed-meshheading:17446240-Female,
pubmed-meshheading:17446240-Humans,
pubmed-meshheading:17446240-Lupus Erythematosus, Systemic,
pubmed-meshheading:17446240-Male,
pubmed-meshheading:17446240-Middle Aged,
pubmed-meshheading:17446240-Myeloblastin,
pubmed-meshheading:17446240-Neutrophil Activation,
pubmed-meshheading:17446240-Neutrophils,
pubmed-meshheading:17446240-Peroxidase,
pubmed-meshheading:17446240-Receptors, Complement 3b,
pubmed-meshheading:17446240-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:17446240-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17446240-Vasculitis
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pubmed:year |
2007
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pubmed:articleTitle |
Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.
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pubmed:affiliation |
Department of Rheumatology and Clinical Immunology, Groningen University Medical Centre, University of Groningen, The Netherlands. c.g.m.kallenberg@int.umcg.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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