Linked Life Data

17435122

Source:http://linkedlifedata.com/resource/pubmed/id/17435122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-7-19
pubmed:abstractText
The availability of the genome sequences of different strains of Francisella tularensis is having a major impact on a wide range of research projects, from understanding the biology of this organism to devising vaccines and diagnostics. Comparative genomics and molecular typing methods suggest that the four different subspecies of F. tularensis are genetically distinct groups. Although there is a high degree of nucleotide identity between strains, there are numerous DNA rearrangements. IS elements appear to have played a major role in these chromosomal rearrangements. The different subspecies of F. tularensis appear to have evolved by vertical descent from a common ancestor, probably F. tularensis subspecies novicida. Comparative genomic and proteomic studies have revealed possible reasons for the different virulence of different strains and a range of candidate virulence genes have been identified including those located on the Francisella pathogenicity island. Proteomic studies have identified proteins which are produced at elevated levels in vivo, and proteins which are recognized by immune or convalescent sera. These proteins might be exploited as components of vaccines or diagnostic systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-121
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Francisella tularensis genomics and proteomics.
pubmed:affiliation
Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK. rwtitball@dstl.gov.uk
pubmed:publicationType
Journal Article, Review