Linked Life Data

17430638

Source:http://linkedlifedata.com/resource/pubmed/id/17430638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-4-13
pubmed:abstractText
Hops (Humulus lupulus, Cannabinaceae) has been used in traditional European medicine as a mild sedative for the treatment of anxiety, nervousness, and insomnia. However, there has been little information available about the underlying sleep inducing mechanism of hops. We have investigated the effects of a hops extract on the rectal body temperature in mice. Hops extract (250 mg kg(-1)) significantly decreased body temperature in male BL6/C57J mice (DeltaT -0.75 +/- 0.07 degrees C) 2 h after oral administration. The effects of the plant extract were comparable with melatonin (50 mg kg(-1); DeltaT -0.66 +/- 0.06 degrees C; 2 h after i.p. injection). The hypothermic effects of melatonin and hops extract were antagonized with the competitive melatonin receptor antagonist luzindole. Thus, our data suggests that the hypothermic--and therefore the sleep-inducing--effects of hops extract are possibly mediated through activation of melatonin receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3573
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
549-52
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice.
pubmed:affiliation
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, PO Box 100494, FL 32610, USA. butterwk@cop.ufl.edu
pubmed:publicationType
Journal Article, Comparative Study