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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-1-9
|
| pubmed:abstractText |
To investigate whether lung 99mTc-DTPA clearance is altered during allograft lung rejection, a group of four double lung and 24 heart-lung transplant patients was studied using serial measurement of the clearance rate of aerosolized 99mTc-DTPA (DTPA-Cl), in association with pulmonary function tests, bronchoalveolar lavage, and transbronchial lung biopsies. Using histologic diagnosis as a standard, we compared 56 episodes with normal lung histology to 32 episodes with allograft lung rejection. A control group of 20 healthy nonsmokers was used to define normal DTPA-Cl. In patients with normal lung histology, DTPA-Cl was higher than in control subjects (2.62 +/- 0.25 versus 1.20 +/- 0.12 %/min; p less than 0.001). In the episodes of allograft lung rejection, DTPA-Cl increased to 3.65 +/- 0.41 %/min (p less than 0.02) as compared with episodes of normal lung histology. The change in DTPA-Cl during allograft lung rejection was correlated (r = 0.3, p less than 0.01) with the increased percentage of lymphocytes in bronchoalveolar lavage (27.8 +/- 3.5% in rejection versus 19.9 +/- 2.2% in normal histology; p less than 0.02). Sensitivity and specificity of DTPA-Cl measurement in detecting lung rejection were 69 and 82%, respectively, versus 45 and 85% for FEV1 measurement. These results suggest that DTPA-Cl monitoring could be used in conjunction with pulmonary function testing as a noninvasive approach for the detection of lung rejection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0003-0805
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
144
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
1333-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1741547-Adult,
pubmed-meshheading:1741547-Biopsy,
pubmed-meshheading:1741547-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:1741547-Female,
pubmed-meshheading:1741547-Graft Rejection,
pubmed-meshheading:1741547-Heart-Lung Transplantation,
pubmed-meshheading:1741547-Humans,
pubmed-meshheading:1741547-Lung,
pubmed-meshheading:1741547-Lung Transplantation,
pubmed-meshheading:1741547-Male,
pubmed-meshheading:1741547-Respiratory Function Tests,
pubmed-meshheading:1741547-Sensitivity and Specificity,
pubmed-meshheading:1741547-Technetium Tc 99m Pentetate
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Increased lung clearance of 99mTcDTPA in allograft lung rejection. The Paris-Sud Lung Transplant Group.
|
| pubmed:affiliation |
Service de Chirugie Thoracique et de Médecine Nuclélaire, Hopital Marie-Lannelongue et Service de Pneumologie, Hopital Antoine Béclère, Université Paris-Sud, France.
|
| pubmed:publicationType |
Journal Article
|