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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-4-18
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pubmed:abstractText |
Oncogene signaling is known to deregulate cell proliferation resulting in uncontrolled growth and cellular transformation. Gene amplification and/or somatic mutations of the HER2/Neu (ErbB2) proto-oncogene occur in approximately 20% of breast cancers. A therapeutic strategy that has been used to block HER2 function is the small molecule tyrosine kinase inhibitor lapatinib. Using human mammary epithelial cells that overexpress HER2, we determined the anti-proliferative effect of lapatinib through measuring the total cell number and analyzing the cell cycle distribution. A mathematical model was used to interpret the experimental data.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-10986055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-11156523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-11252954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-11533657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-11965249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-12909255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-1350088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-14117037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-15044465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-15087399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-15158434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-15684311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16091755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16195878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16418322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16452222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16516246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16697424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16843263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16861913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-16894399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-1713661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-2250141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-2470152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-4933846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-7538656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17407594-7819273
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1742-4682
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14
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pubmed:dateRevised |
2010-9-15
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pubmed:meshHeading |
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pubmed:year |
2007
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pubmed:articleTitle |
relocating job wise? A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor.
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pubmed:affiliation |
Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA. peter.hinow@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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