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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-3-26
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pubmed:abstractText |
It has frequently been suggested that loss of beta 2-microglobulin (beta 2m) in tumor cells may lead to malignant progression due to escape from immunological recognition. Here, we directly tested the role of beta 2m expression in tumorigenicity. A beta 2 m loss mutant (C4.4-25-), selected from the murine lymphoma EL-4, showed a marked reduction in tumorigenicity as compared with EL-4 in normal C57B1/6 (B6) mice. The reduced tumorigenicity was directly related to beta 2 m expression. Transfection of an intact murine beta 2m gene markedly increased the tumorigenic potential. The reduced tumorigenicity of C4.4-25- compared with beta 2m transfected cells was observed also in athymic B6 nu/nu mice, but was abolished in B6 mice depleted of natural killer (NK) 1.1-positive cells. These results show that restoration of beta 2m expression can promote tumorigenicity and demonstrate for the first time that induction of major histocompatibility complex class I expression by transfection can lead to escape from NK cells in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-1856626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-1912514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-1987491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-2113557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-2201309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-2642530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-2660144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-2678947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-2814488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-3171481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-3186742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-3584981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-3877776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-3951539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1740666-7016338
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1740666-Animals,
pubmed-meshheading:1740666-Cell Separation,
pubmed-meshheading:1740666-Flow Cytometry,
pubmed-meshheading:1740666-Humans,
pubmed-meshheading:1740666-Mice,
pubmed-meshheading:1740666-Mice, Nude,
pubmed-meshheading:1740666-Mutation,
pubmed-meshheading:1740666-Phenotype,
pubmed-meshheading:1740666-Transfection,
pubmed-meshheading:1740666-Tumor Cells, Cultured,
pubmed-meshheading:1740666-beta 2-Microglobulin
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pubmed:year |
1992
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pubmed:articleTitle |
Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells.
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pubmed:affiliation |
Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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