Linked Life Data

17397244

Source:http://linkedlifedata.com/resource/pubmed/id/17397244

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-4-2
pubmed:abstractText
With cardiovascular (CV)-related disorders accounting for the highest mortality rates in the world, affecting the quantity and quality of life of patients and creating an economic burden of prolonged therapeutic intervention, there is great significance in understanding the cellular and molecular alterations that influence the progression of these pathologies. The cellular genotype is regulated by the DNA component, whilst the cellular phenotype is influenced by the protein complement. By improving the understanding of the molecular mechanisms that influence the protein profile, the pathologies that influence the intrinsic functions of the CV system may be detected earlier or managed more efficiently. This is achievable with technologies encompassed by 'proteomics.' Proteomic investigations of CV diseases, including dilated cardiomyopathy (DCM), atherosclerosis, and ischemia/reperfusion (I/R) injury, have identified candidate proteins altered with the pathologic states, complementing past biochemical and physiologic observations. Whilst proteomics is still a relatively new discipline to be applied to the basic scientific investigation of CV diseases, it is emerging as a technique to screen for potential biomarkers in both tissues/cells and biologic fluids (biofluids), as well as to identify the targets of existing therapeutics. By enabling the separation of complex mixtures over numerous dimensions, exploiting the intrinsic properties of proteins, including charge state, molecular mass, and hydrophobicity, in addition to cellular location, the discrete alterations within the cell may be resolved. Proteomics has shown alterations to myofilament proteins including troponin I and myosin light chain, correlating with the reduction in contractility in the myocardium from DCM and I/R. The diverse cell types that coalesce to induce atherosclerotic plaque formation have been investigated both collectively and individually to elucidate the influence of the modifications to single cell types on the developing plaque as a whole. Proteomics has also been used to observe changes to biofluids occurring with these pathologies, a new potential link between basic science and clinical applications. The development of CV proteomics has helped to identify a number of possible protein candidates, and offers the potential to treat and diagnose CV disease more effectively in the future.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/N0 NV 28180, http://linkedlifedata.com/resource/pubmed/grant/N01 HV028180, http://linkedlifedata.com/resource/pubmed/grant/P01 HL077180, http://linkedlifedata.com/resource/pubmed/grant/P01 HL077180-010001, http://linkedlifedata.com/resource/pubmed/grant/P01 HL077180-020001, http://linkedlifedata.com/resource/pubmed/grant/P01 HL077180-030001, http://linkedlifedata.com/resource/pubmed/grant/P01 HL077180-040001, http://linkedlifedata.com/resource/pubmed/grant/P01 HL077180-050001, http://linkedlifedata.com/resource/pubmed/grant/P01 HL081427-010003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL081427-020003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL081427-030003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL081427-040003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL081427-050003, http://linkedlifedata.com/resource/pubmed/grant/P01HL081427, http://linkedlifedata.com/resource/pubmed/grant/P50 HL084946-019003, http://linkedlifedata.com/resource/pubmed/grant/P50 HL084946-029003, http://linkedlifedata.com/resource/pubmed/grant/P50 HL084946-039003
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1177-1062
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-95
pubmed:dateRevised
2010-8-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cardiovascular proteomics: past, present, and future.
pubmed:affiliation
Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural