Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-3-28
pubmed:abstractText
Vesicular traffic in the Drosophila melanogaster oocyte occurs actively during vitellogenesis. Although endocytosis in the oocyte has been well characterized, exocytic vesicular traffic is less well understood. We show that the oocyte endoplasmic reticulum (ER) becomes concentrated into subcortical clusters during vitellogenesis. This ER reorganization requires Jagunal, which is an evolutionarily conserved ER membrane protein. Loss of Jagunal reduces vesicular traffic to the oocyte lateral membrane, but does not affect posterior polarized vesicular traffic, suggesting a role for Jagunal in facilitating vesicular traffic in the subcortex. Reduced membrane traffic caused by loss of Jagunal affects oocyte and bristle growth. We propose that ER reorganization is an important mechanism used by cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process through ER clustering.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
176
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
941-52
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:17389229-Animals, pubmed-meshheading:17389229-Golgi Apparatus, pubmed-meshheading:17389229-Drosophila melanogaster, pubmed-meshheading:17389229-Membrane Proteins, pubmed-meshheading:17389229-Base Sequence, pubmed-meshheading:17389229-Cell Differentiation, pubmed-meshheading:17389229-Endoplasmic Reticulum, pubmed-meshheading:17389229-Amino Acid Sequence, pubmed-meshheading:17389229-Microscopy, Electron, Transmission, pubmed-meshheading:17389229-Cytoplasmic Streaming, pubmed-meshheading:17389229-Molecular Sequence Data, pubmed-meshheading:17389229-Oocytes, pubmed-meshheading:17389229-Protein Transport, pubmed-meshheading:17389229-Oogenesis, pubmed-meshheading:17389229-Sequence Homology, Amino Acid, pubmed-meshheading:17389229-Exocytosis, pubmed-meshheading:17389229-Caenorhabditis elegans, pubmed-meshheading:17389229-Drosophila Proteins
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