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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-16
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pubmed:abstractText |
Chronic metabolic acidosis induces net Ca efflux from bone; this osteoclastic bone resorption is mediated by increased osteoblastic prostaglandin synthesis. Cyclooxygenase, the rate-limiting enzyme in prostaglandin synthesis, is present in both constitutive (COX-1) and inducible (COX-2) forms. We report here that acidosis increases both osteoblastic RNA and protein levels for COX-2 and that genetic deficiency or pharmacologic inhibition of COX-2 significantly reduces acid-induced Ca efflux from bone.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
907-17
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17352658-Acidosis,
pubmed-meshheading:17352658-Animals,
pubmed-meshheading:17352658-Animals, Newborn,
pubmed-meshheading:17352658-Bone Resorption,
pubmed-meshheading:17352658-Bone and Bones,
pubmed-meshheading:17352658-Calcium,
pubmed-meshheading:17352658-Cells, Cultured,
pubmed-meshheading:17352658-Culture Media,
pubmed-meshheading:17352658-Cyclooxygenase 1,
pubmed-meshheading:17352658-Cyclooxygenase 2,
pubmed-meshheading:17352658-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:17352658-Dinoprostone,
pubmed-meshheading:17352658-Gene Expression,
pubmed-meshheading:17352658-Genotype,
pubmed-meshheading:17352658-Hydrogen-Ion Concentration,
pubmed-meshheading:17352658-Immunoblotting,
pubmed-meshheading:17352658-Membrane Proteins,
pubmed-meshheading:17352658-Mice,
pubmed-meshheading:17352658-Mice, Inbred Strains,
pubmed-meshheading:17352658-Mice, Knockout,
pubmed-meshheading:17352658-Nitrobenzenes,
pubmed-meshheading:17352658-Organ Culture Techniques,
pubmed-meshheading:17352658-Osteoblasts,
pubmed-meshheading:17352658-RNA,
pubmed-meshheading:17352658-Skull,
pubmed-meshheading:17352658-Sulfonamides,
pubmed-meshheading:17352658-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro.
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pubmed:affiliation |
Department of Medicine, Division of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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