Source:http://linkedlifedata.com/resource/pubmed/id/17341301
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-7-3
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pubmed:abstractText |
CTLA-4 encodes cytotoxic T lymphocyte-associated antigen-4, a cell-surface molecule providing a negative signal for T-cell activation. CTLA-4 gene polymorphisms have been widely studied in connection with genetic susceptibility to various autoimmune diseases, but studies have led to contradictory results in different populations. This case-control study sought to investigate whether CTLA-4 CT60 and/or +49A/G polymorphisms were involved in the genetic predisposition to primary Sjögren syndrome (pSS). We analysed CTLA-4 CT60 and +49A/G polymorphisms in a first cohort of 142 patients with pSS (cohort 1) and 241 controls, all of Caucasian origin. A replication study was performed on a second cohort of 139 patients with pSS (cohort 2). In cohort 1, the CTLA-4 +49A/G*A allele was found on 73% of chromosomes in patients with pSS, compared with 66% in controls (p = 0.036; odds ratio (OR) 1.41, 95% confidence interval (CI) 1.02 to 1.95). No difference in CTLA-4 CT60 allelic or genotypic distribution was observed between patients (n = 142) and controls (n = 241). In the replication cohort, the CTLA-4 +49A/G*A allele was found on 62% of chromosomes in patients with pSS, compared with 66% in controls (p = 0.30; OR 0.85, 95% CI 0.63 to 1.16). Thus, the CTLA-4 +49A/G*A allele excess among patients from cohort 1 was counterbalanced by its under-representation in cohort 2. When the results from the patients in both cohorts were pooled (n = 281), there was no difference in CTLA-4 +49A/G allelic or genotypic distribution in comparison with controls. Our results demonstrate a lack of association between CTLA-4 CT60 or +49A/G polymorphisms and pSS. Premature conclusions might have been made if a replication study had not been performed. These results illustrate the importance of case-control studies performed on a large number of patients. In fact, sampling bias may account for some contradictory results previously reported for CTLA-4 association studies in autoimmune diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-10189842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-11196709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-11726229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-12006334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-12724780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-16248997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-16869018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17341301-17559691
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1478-6362
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pubmed:author |
pubmed-author:AzarianMariamM,
pubmed-author:CagnardNicolasN,
pubmed-author:CharronDominiqueD,
pubmed-author:ChenChunC,
pubmed-author:GottenbergJacques-EricJE,
pubmed-author:HachullaEricE,
pubmed-author:LoiseauPascaleP,
pubmed-author:MarietteXavierX,
pubmed-author:Miceli-RichardCorinneC,
pubmed-author:PuechalXavierX,
pubmed-author:SibiliaJeanJ
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R24
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17341301-Antigens, CD,
pubmed-meshheading:17341301-Antigens, Differentiation,
pubmed-meshheading:17341301-CTLA-4 Antigen,
pubmed-meshheading:17341301-Case-Control Studies,
pubmed-meshheading:17341301-Gene Frequency,
pubmed-meshheading:17341301-Genetic Predisposition to Disease,
pubmed-meshheading:17341301-Humans,
pubmed-meshheading:17341301-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:17341301-Selection Bias,
pubmed-meshheading:17341301-Sjogren's Syndrome
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pubmed:year |
2007
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pubmed:articleTitle |
CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome.
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pubmed:affiliation |
Rhumatologie, Institut Pour la Santé et la Recherche Médicale U802, Université Paris-Sud 11, Hôpital Bicêtre, 78 rue du Général Leclerc, Assistance Publique-Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France. jegotten@club-internet.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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