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rdf:type |
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lifeskim:mentions |
umls-concept:C0030190,
umls-concept:C0030191,
umls-concept:C0032145,
umls-concept:C0032659,
umls-concept:C0240321,
umls-concept:C0314603,
umls-concept:C1367601,
umls-concept:C1417760,
umls-concept:C1418252,
umls-concept:C1420455,
umls-concept:C1511726,
umls-concept:C1698947,
umls-concept:C1705527,
umls-concept:C1705832,
umls-concept:C1708726
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pubmed:issue |
4
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pubmed:dateCreated |
2007-6-4
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pubmed:abstractText |
In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT)n; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT5 (TG)14(TA)12; 8p12-q11.2) and Plasminogen Activator Inhibitor-1 (PAI-1 (CA)n; 7q21.3-q22), (3) Oxidative metabolism: the inducible nitric oxide (NO) synthase (iNOS) gene (NOS2A (CCTTT)n; 17cen-q11.2). Allele frequencies for these four STR loci were investigated in several Mediterranean populations. The population data deviate from the Hardy-Weinberg equilibrium in all populations for GpIIIa (CT)n polymorphism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1344-6223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-20
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:17320454-Africa, Northern,
pubmed-meshheading:17320454-Alleles,
pubmed-meshheading:17320454-Chi-Square Distribution,
pubmed-meshheading:17320454-Data Interpretation, Statistical,
pubmed-meshheading:17320454-European Continental Ancestry Group,
pubmed-meshheading:17320454-France,
pubmed-meshheading:17320454-Gene Frequency,
pubmed-meshheading:17320454-Genetics, Population,
pubmed-meshheading:17320454-Humans,
pubmed-meshheading:17320454-Integrin beta3,
pubmed-meshheading:17320454-Italy,
pubmed-meshheading:17320454-Mediterranean Region,
pubmed-meshheading:17320454-Microsatellite Repeats,
pubmed-meshheading:17320454-Nitric Oxide Synthase Type II,
pubmed-meshheading:17320454-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:17320454-Polymerase Chain Reaction,
pubmed-meshheading:17320454-Polymorphism, Genetic,
pubmed-meshheading:17320454-Sicily,
pubmed-meshheading:17320454-Spain,
pubmed-meshheading:17320454-Tissue Plasminogen Activator
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pubmed:year |
2007
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pubmed:articleTitle |
Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations.
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pubmed:affiliation |
Department of Human Genetics, Faculty of Science, University of Corsica, BP52 20250 Corte Corsica, France. falchi@univ-corse.fr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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