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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-13
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pubmed:abstractText |
NMDA receptors promote neuronal survival but also cause cell degeneration and neuron loss. The mechanisms underlying these opposite effects on neuronal fate are unknown. Whole-genome expression profiling revealed that NMDA receptor signaling is decoded at the genomic level through activation of two distinct, largely nonoverlapping gene-expression programs. The location of the NMDA receptor activated specifies the transcriptional response: synaptic NMDA receptors induce a coordinate upregulation of newly identified pro-survival genes and downregulation of pro-death genes. Extrasynaptic NMDA receptors fail to activate this neuroprotective program, but instead induce expression of Clca1, a putative calcium-activated chloride channel that kills neurons. These results help explain the opposing roles of synaptic and extrasynaptic NMDA receptors on neuronal fate. They also demonstrate that the survival function is implemented in neurons through a multicomponent system of functionally related genes, whose coordinate expression is controlled by specific calcium signal initiation sites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chloride Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Clca1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/enhanced green fluorescent protein
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-4199
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
549-62
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pubmed:meshHeading |
pubmed-meshheading:17296556-Animals,
pubmed-meshheading:17296556-Bicuculline,
pubmed-meshheading:17296556-Calcium,
pubmed-meshheading:17296556-Cell Death,
pubmed-meshheading:17296556-Cell Survival,
pubmed-meshheading:17296556-Cells, Cultured,
pubmed-meshheading:17296556-Chloride Channels,
pubmed-meshheading:17296556-Dependovirus,
pubmed-meshheading:17296556-Dizocilpine Maleate,
pubmed-meshheading:17296556-Electric Stimulation,
pubmed-meshheading:17296556-Excitatory Amino Acid Antagonists,
pubmed-meshheading:17296556-GABA Antagonists,
pubmed-meshheading:17296556-Gene Expression Regulation,
pubmed-meshheading:17296556-Genome,
pubmed-meshheading:17296556-Glutamic Acid,
pubmed-meshheading:17296556-Green Fluorescent Proteins,
pubmed-meshheading:17296556-Hippocampus,
pubmed-meshheading:17296556-Mice,
pubmed-meshheading:17296556-Mice, Inbred C57BL,
pubmed-meshheading:17296556-Neurons,
pubmed-meshheading:17296556-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17296556-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:17296556-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death.
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pubmed:affiliation |
Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, 69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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