Linked Life Data

17275930

Source:http://linkedlifedata.com/resource/pubmed/id/17275930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-2-28
pubmed:abstractText
5-Hydroxytryptamine (5-HT), dopamine and norepinephrine are important monoamine neurotransmitters implicated in multiple brain mechanisms and regulated by high-affinity transmembrane monoamine transporters. Although knockout mice lacking 5-HT, dopamine or norepinephrine transporters are widely used to assess brain monoamine processes, these models have several methodological limitations. There is mounting evidence that heterozygous mutant mice with reduced (but not abolished) monoamine transporter functions could provide models with greater relevance to the genetics of human disorders, which only rarely involve complete loss-of-function mutations. Here, we discuss why heterozygous mouse models, in addition to knockout mice, might be useful for brain monoamine transporter research.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0165-6147
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
122-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The developing use of heterozygous mutant mouse models in brain monoamine transporter research.
pubmed:affiliation
Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Drive, 1264 Bethesda, MD 20892-1264, USA. kalueva@mail.nih.gov
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Intramural