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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-3-29
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pubmed:abstractText |
Cyclooxygenase (COX)-1 and COX-2 produce prostanoids from arachidonic acid and are thought to have important yet distinct roles in normal brain function. Deletion of COX-1 or COX-2 results in profound differences both in brain levels of prostaglandin E2 and in activation of the transcription factor nuclear factor-kappaB, suggesting that COX-1 and COX-2 play distinct roles in brain arachidonic acid metabolism and regulation of gene expression. To further elucidate the role of COX isoforms in the regulation of the brain transcriptome, microarray analysis of gene expression in the cerebral cortex and hippocampus of mice deficient in COX-1 (COX-1-/-) or COX-2 (COX-2-/-) was performed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10374907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10426546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10592344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10668482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10693935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10709637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10792135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10900018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10966456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-10995836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-11028754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-11158633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-11305326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-11325033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-11337507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-11846609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-12707371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-14561922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-15093951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-15560112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-15584915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-15878334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16055227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16099403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16176262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16405503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16418805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16456667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16517747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-16787416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-2479580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-6875555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-7738031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-8113801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-8738166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-9149101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-9175157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-9597132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-9693110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17266762-9771750
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-6914
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R14
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17266762-Animals,
pubmed-meshheading:17266762-Cerebral Cortex,
pubmed-meshheading:17266762-Cyclooxygenase 1,
pubmed-meshheading:17266762-Cyclooxygenase 2,
pubmed-meshheading:17266762-GABA Plasma Membrane Transport Proteins,
pubmed-meshheading:17266762-Gene Expression Profiling,
pubmed-meshheading:17266762-Gene Expression Regulation,
pubmed-meshheading:17266762-Genotype,
pubmed-meshheading:17266762-Hippocampus,
pubmed-meshheading:17266762-Janus Kinases,
pubmed-meshheading:17266762-Methionine,
pubmed-meshheading:17266762-Mice,
pubmed-meshheading:17266762-Mice, Knockout,
pubmed-meshheading:17266762-Oxidation-Reduction,
pubmed-meshheading:17266762-Receptors, GABA,
pubmed-meshheading:17266762-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain.
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pubmed:affiliation |
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. toscanoc@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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