Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-5-12
|
| pubmed:abstractText |
The distribution of endothelin-1 (ET-1) receptors on human vascular tissue has been studied. High- and low-resolution autoradiography was used to determine the distribution of [125]ET binding sites in human blood vessels and ventricular myocardium. Dense, displaceable [125I]ET binding was associated with cardiac myocytes and the smooth muscle layer of all vessels were examined. There was also dense binding to vasa vasora. There was increased [125I]ET binding to atheromatous coronary arteries and vein graft, which was associated with the tunica media and vasa vasora or regions of neovascularization. Vasoconstrictor and positive inotropic activity of ET-1 has been established in vitro. The vasoconstrictor effect of ET-1 is likely to be mediated via the binding sites identified on vascular smooth muscle. The striking perivascular [125I]ET-1 binding suggests that ET-1 may also have constrictor activity on vasa vasora. There is experimental evidence that ET-1 has mitogenic activity on vascular smooth muscle cells in culture. The increased binding to both smooth muscle and regions of neovascularization in atheromatous vessels suggests that ET-1 may play a role in atherosclerosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17 Suppl 7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S458-62
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1725412-Adolescent,
pubmed-meshheading:1725412-Adult,
pubmed-meshheading:1725412-Aged,
pubmed-meshheading:1725412-Arteriosclerosis,
pubmed-meshheading:1725412-Autoradiography,
pubmed-meshheading:1725412-Binding Sites,
pubmed-meshheading:1725412-Blood Vessels,
pubmed-meshheading:1725412-Child,
pubmed-meshheading:1725412-Child, Preschool,
pubmed-meshheading:1725412-Coronary Vessels,
pubmed-meshheading:1725412-Endothelins,
pubmed-meshheading:1725412-Female,
pubmed-meshheading:1725412-Humans,
pubmed-meshheading:1725412-Infant,
pubmed-meshheading:1725412-Iodine Radioisotopes,
pubmed-meshheading:1725412-Male,
pubmed-meshheading:1725412-Middle Aged,
pubmed-meshheading:1725412-Myocardium,
pubmed-meshheading:1725412-Receptors, Cell Surface,
pubmed-meshheading:1725412-Receptors, Endothelin
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Autoradiographic localization of [125I]endothelin binding sites in human blood vessels and coronary tissue: functional correlates.
|
| pubmed:affiliation |
NHLI, Harefield Hospital, Middlesex, U.K.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|