Linked Life Data

17251265

Source:http://linkedlifedata.com/resource/pubmed/id/17251265

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-2-12
pubmed:abstractText
In the developing eye of Drosophila, the EGFR and Notch pathways integrate in a sequential, followed by a combinatorial, manner in the specification of cone-cell fate. Here, we demonstrate that the specification of primary pigment cells requires the reiterative use of the sequential integration between the EGFR and Notch pathways to regulate the spatiotemporal expression of Delta in pupal cone cells. The Notch signal from the cone cells then functions in the direct specification of primary pigment-cell fate. EGFR requirement in this process occurs indirectly through the regulation of Delta expression. Combined with previous work, these data show that unique combinations of only two pathways--Notch and EGFR--can specify at least five different cell types within the Drosophila eye.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
825-31
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:17251265-Animals, pubmed-meshheading:17251265-Body Patterning, pubmed-meshheading:17251265-Cell Differentiation, pubmed-meshheading:17251265-DNA-Binding Proteins, pubmed-meshheading:17251265-Drosophila, pubmed-meshheading:17251265-Drosophila Proteins, pubmed-meshheading:17251265-Eye, pubmed-meshheading:17251265-Eye Proteins, pubmed-meshheading:17251265-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:17251265-Membrane Proteins, pubmed-meshheading:17251265-Photoreceptor Cells, Invertebrate, pubmed-meshheading:17251265-Pigment Epithelium of Eye, pubmed-meshheading:17251265-Pupa, pubmed-meshheading:17251265-Receptor, Epidermal Growth Factor, pubmed-meshheading:17251265-Receptors, Notch, pubmed-meshheading:17251265-Signal Transduction, pubmed-meshheading:17251265-Transcription Factors
pubmed:year
2007
pubmed:articleTitle
Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye.
pubmed:affiliation
Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural