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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-2-12
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pubmed:abstractText |
ThIL-17 (IL-17+/IFN-gamma-) cell lines are significantly more encephalitogenic than Th1 (IL-17-/IFN-gamma+) cell lines in adoptive transfer EAE models. In actively induced EAE short ex vivo peptide stimulation identifies an IL-17+/IFN-gamma+ population of CD4+ CNS-infiltrating MOG35-55-specific T cells, which outnumber IL-17+/IFN-gamma- cells by approximately 3:1 as disease develops. A decrease in numbers of IL-17+/IFN-gamma+ cells following in vitro culture is accompanied by an increase in IL-17-/IFN-gamma+ cell numbers. Together these ex vivo and in vitro observations imply that the Th1 lineage is more encephalitogenic than is suggested by adoptive transfer of Th1 (IL-17-/IFN-gamma+) cell lines which have been terminally differentiated in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-103
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17240458-Animals,
pubmed-meshheading:17240458-Cell Proliferation,
pubmed-meshheading:17240458-Central Nervous System,
pubmed-meshheading:17240458-Cytokines,
pubmed-meshheading:17240458-Disease Models, Animal,
pubmed-meshheading:17240458-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:17240458-Flow Cytometry,
pubmed-meshheading:17240458-Glycoproteins,
pubmed-meshheading:17240458-Interferon-gamma,
pubmed-meshheading:17240458-Interleukin-17,
pubmed-meshheading:17240458-Mice,
pubmed-meshheading:17240458-Mice, Inbred C57BL,
pubmed-meshheading:17240458-Peptide Fragments,
pubmed-meshheading:17240458-Th1 Cells,
pubmed-meshheading:17240458-Thymidine,
pubmed-meshheading:17240458-Tritium
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pubmed:year |
2007
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pubmed:articleTitle |
An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis.
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pubmed:affiliation |
The Garvan Institute of Medical Research, Department of Inflammation, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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