Linked Life Data

17239848

Source:http://linkedlifedata.com/resource/pubmed/id/17239848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-19
pubmed:abstractText
The mechanisms for cell fate determination have been extensively studied whereas little is known about the mechanism through which functional specificity is established. In the Drosophila midgut, copper cells provide an excellent model system to examine this mechanism. Copper is an essential element for the activity of a number of physiologically important enzymes including Cu/Zn-superoxide dismutase, cytochrome c oxidase, and dopamine-beta-hydroxylase. Drosophila copper cells are involved in two distinct functions, i.e., copper absorption and acid secretion, which are visualized as a fluorescent signal and a color change of a pH indicator dye, respectively. Here we show that the absorptive function is established through two independent pathways, the Notch signaling pathway in adjacent interstitial cells and the Wingless signaling pathway in copper cells. Furthermore, the other function, acid secretion, is regulated through the Decapentaplegic and Wingless signaling pathways in interstitial cells. Our results clearly indicate that normal morphological development is insufficient for functional maturation, and that subsequent functional specification is achieved through several independent pathways. These results provide valuable insights into the molecular mechanism underlying functional specification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
304
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-61
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Notch-, Wingless-, and Dpp-mediated signaling pathways are required for functional specification of Drosophila midgut cells.
pubmed:affiliation
Graduate School of Natural and Science Technology, Okayama University, 3-1-1 Tsushima-naka, Okayama 700-8530, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't