Linked Life Data

17230546

Source:http://linkedlifedata.com/resource/pubmed/id/17230546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-1-24
pubmed:abstractText
[(18)F]SPA-RQ (substance P antagonist receptor quantifier) labels the substance P-preferring (NK(1)) receptor in human brain. A prior study showed that [(18)F]SPA-RQ brain uptake can be quantified with a reference tissue method and thereby avoid invasive blood sampling. The purposes of this study were to compare three different reference tissue methods and to assess test-retest reproducibility. Eight healthy subjects underwent two [(18)F]SPA-RQ scans. We calculated the binding potential (BP), which is proportional to receptor density, from both regional volume of interest and voxel-wise data. We compared three reference tissue methods: simplified reference tissue model, multilinear reference tissue model (MRTM), and its two-parameter version (MRTM2). The three methods generated equivalent values of regional BP, but MRTM2 was the most resistant to noise. Temporally stable values of BP were obtained with 240 min of imaging data. MRTM2 had excellent test-retest reproducibility, with high reliability (intraclass correlation > 0.9) and low variability (< 10%). In addition to regional volume of interest analysis, we also created parametric images of BP, variability, and reliability based on voxel-wise time-activity data. The reproducibility of parametric BP was also good, with variability < 20% and reliability > 0.7 in gray matter regions. In conclusion, a two-parameter reference tissue method (MRTM2) provided reproducible and reliable measurements of [(18)F]SPA-RQ brain uptake using 240 min of both regional and voxel-wise data.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0887-4476
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
242-51
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17230546-Adult, pubmed-meshheading:17230546-Brain, pubmed-meshheading:17230546-Brain Mapping, pubmed-meshheading:17230546-Female, pubmed-meshheading:17230546-Fluorine Radioisotopes, pubmed-meshheading:17230546-Humans, pubmed-meshheading:17230546-Image Interpretation, Computer-Assisted, pubmed-meshheading:17230546-Linear Models, pubmed-meshheading:17230546-Male, pubmed-meshheading:17230546-Middle Aged, pubmed-meshheading:17230546-Piperidines, pubmed-meshheading:17230546-Positron-Emission Tomography, pubmed-meshheading:17230546-Receptors, Neurokinin-1, pubmed-meshheading:17230546-Reference Values, pubmed-meshheading:17230546-Reproducibility of Results, pubmed-meshheading:17230546-Sensitivity and Specificity, pubmed-meshheading:17230546-Tetrazoles, pubmed-meshheading:17230546-Time Factors
pubmed:year
2007
pubmed:articleTitle
PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility.
pubmed:affiliation
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA. yasunof@mail.nih.gov
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural