Linked Life Data

17208217

Source:http://linkedlifedata.com/resource/pubmed/id/17208217

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-2-19
pubmed:abstractText
Here we report a new role for the small GTPase RhoC in the control of limb chondrogenesis. Expression of rhoC is a precocious marker of the zeugopodial and digit blastemas and is induced by treatments with TGFbetas preceding the formation of ectopic digits. As development progresses, expression of rhoC outlines the growing distal tip of the digits, and marks the regions of interphalangeal joint formation. Functional experiments show that RhoC is a negative regulator of chondrogenesis, which controls digit outgrowth and joint segmentation. These functions appear to be mediated by reorganization of the actin cytoskeleton and modification of the adhesive properties of the mesenchymal cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
303
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-35
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Role of RhoC in digit morphogenesis during limb development.
pubmed:affiliation
Departamento de Anatomía y Biología Celular, Facultad de Medicina, Universidad de Cantabria, C/Cardenal Herrera Oria s/n, Santander 39011, Spain. monteroja@unican.es
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't