Linked Life Data

17203776

Source:http://linkedlifedata.com/resource/pubmed/id/17203776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6B
pubmed:dateCreated
2007-1-5
pubmed:abstractText
Myocardial hypertrophy is associated with specific histological changes, which are representative of the cardiomyocytes cellular response to overload. Evidently, transcriptional modulation of specific genes is implicated in myocardial hypertrophy. Recently, the parathyroid hormone-related protein (PTHrP)/PTH-1 receptor (PTH-1.R) bioregulation system was shown to participate in specific regulatory processes of the cardiomyocyte function and proliferation, which can be related to cardiac hypertrophy and heart failure. We review the literature on the pathophysiology of cardiac hypertrophy vis-a-vis the role of PTHrP/PTH-1.R system as a good therapeutic target.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0258-851X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
837-44
pubmed:meshHeading
pubmed:articleTitle
The PTHrP/PTH.1-R bioregulation system in cardiac hypertrophy: possible therapeutic implications.
pubmed:affiliation
Department of Experimental Physiology, , University of Athens, Medical School, Greece.
pubmed:publicationType
Journal Article, Review