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rdf:type |
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lifeskim:mentions |
umls-concept:C0019564,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0037083,
umls-concept:C0080093,
umls-concept:C0205251,
umls-concept:C0376249,
umls-concept:C0563533,
umls-concept:C0596235,
umls-concept:C0920644,
umls-concept:C1152805,
umls-concept:C1710082
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pubmed:issue |
2
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
Extremely low frequency (ELF<300Hz) electromagnetic fields affect several neuronal activities including memory. Because ELF magnetic fields cause altered Ca(2+) homeostasis in neural tissues, we examined their influence on Ca(2+) signaling enzymes in hippocampus and related them with NMDA receptor functions. Hippocampal regions were obtained from brains of 21-day-old rats that were exposed for 90 days to 50Hz magnetic fields at 50 and 100 microT intensities. In comparison to controls, ELF exposure caused increased intracellular Ca(2+) levels concomitant with increased activities of Ca(2+)-dependent protein kinase C (PKC), cAMP-dependent protein kinase and calcineurin as well as decreased activity of Ca(2+)-calmodulin-dependent protein kinase in hippocampal regions. Simultaneous ligand-binding studies revealed decreased binding to N-methyl-D-aspartic acid (NMDA) receptors. The combined results suggest that perturbed neuronal functions caused by ELF exposure may involve altered Ca(2+) signaling events contributing to aberrant NMDA receptor activities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
413
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17196332-Animals,
pubmed-meshheading:17196332-Binding, Competitive,
pubmed-meshheading:17196332-Calcineurin,
pubmed-meshheading:17196332-Calcium,
pubmed-meshheading:17196332-Calcium Signaling,
pubmed-meshheading:17196332-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:17196332-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:17196332-Electromagnetic Fields,
pubmed-meshheading:17196332-Glutamic Acid,
pubmed-meshheading:17196332-Hippocampus,
pubmed-meshheading:17196332-Male,
pubmed-meshheading:17196332-Memory Disorders,
pubmed-meshheading:17196332-Protein Kinase C,
pubmed-meshheading:17196332-Rats,
pubmed-meshheading:17196332-Rats, Wistar,
pubmed-meshheading:17196332-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:17196332-Synaptic Transmission
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pubmed:year |
2007
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pubmed:articleTitle |
Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus.
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pubmed:affiliation |
Department of Biochemistry, Osmania University, Hyderabad 500007, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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