Linked Life Data

17184777

Source:http://linkedlifedata.com/resource/pubmed/id/17184777

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-26
pubmed:abstractText
Cul5-based complex is a member of ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) ubiquitin ligase family. The cellular function of the Cul5-based complex is poorly understood. In this study, we found that oocyte septum formation and egg production did not occur in either cul-5- or rbx-2-depleted cul-2 homozygotes, although control cul-2 homozygotes laid approximately 50 eggs. These phenotypes are reminiscent of those caused by the MAP kinase mpk-1 depletion. In fact, activation of MPK-1 was significantly inhibited in cul-5-depleted cul-2 mutant and cul-2-depleted cul-5 mutant. Yeast two-hybrid analysis and RNAi-knockdown experiments suggest that oocyte maturation from pachytene exit and MPK-1 activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1-CUL-2-based complexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
581
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-50
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17184777-Animals, pubmed-meshheading:17184777-Animals, Genetically Modified, pubmed-meshheading:17184777-Caenorhabditis elegans, pubmed-meshheading:17184777-Caenorhabditis elegans Proteins, pubmed-meshheading:17184777-Cullin Proteins, pubmed-meshheading:17184777-Enzyme Activation, pubmed-meshheading:17184777-Female, pubmed-meshheading:17184777-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:17184777-Multiprotein Complexes, pubmed-meshheading:17184777-Mutation, pubmed-meshheading:17184777-Oocytes, pubmed-meshheading:17184777-Oogenesis, pubmed-meshheading:17184777-Ovoviviparity, pubmed-meshheading:17184777-Pachytene Stage, pubmed-meshheading:17184777-Protein-Serine-Threonine Kinases, pubmed-meshheading:17184777-RNA, Small Interfering, pubmed-meshheading:17184777-Ubiquitin-Protein Ligases
pubmed:year
2007
pubmed:articleTitle
C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1.
pubmed:affiliation
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't