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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003873,
umls-concept:C0022417,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0030705,
umls-concept:C0035435,
umls-concept:C0039099,
umls-concept:C0040300,
umls-concept:C0085112,
umls-concept:C0086418,
umls-concept:C0332835,
umls-concept:C1539477,
umls-concept:C1956325
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|
pubmed:issue |
2
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pubmed:dateCreated |
2007-1-11
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|
pubmed:abstractText |
We investigated the tissue distribution of a humanized anti-human Fas monoclonal antibody, R-125224, in SCID mice transplanted with synovial tissues from patients with rheumatoid arthritis (SCID-HuRAg mice). The binding kinetics of R-125224 was also determined, using isolated human synovial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0724-8741
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
310-7
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pubmed:meshHeading |
pubmed-meshheading:17180729-Animals,
pubmed-meshheading:17180729-Antibodies,
pubmed-meshheading:17180729-Antigens, CD95,
pubmed-meshheading:17180729-Arthritis, Rheumatoid,
pubmed-meshheading:17180729-Cell Separation,
pubmed-meshheading:17180729-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:17180729-Humans,
pubmed-meshheading:17180729-Injections, Intravenous,
pubmed-meshheading:17180729-Iodine Radioisotopes,
pubmed-meshheading:17180729-Joints,
pubmed-meshheading:17180729-Mice,
pubmed-meshheading:17180729-Mice, SCID,
pubmed-meshheading:17180729-Synovial Membrane,
pubmed-meshheading:17180729-Tissue Distribution
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
In SCID mice with transplanted joint tissues from rheumatism patients, a model mice of human rheumatoid arthritis, anti-human fas antibody (R-125224) distributes specifically to human synovium.
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pubmed:affiliation |
Drug Metabolism and Pharmacokinetics Research Laboratories, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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