|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-3-12
|
|
pubmed:abstractText |
The dopaminergic pathway may be of interest in assessing risk of non-small cell lung cancer (NSCLC). Dopamine receptors are expressed in alveolar epithelial cells and human lung tumours, and dopamine inhibits both cell proliferation in vitro and growth of lung tumour xenografts in nude mice. Moreover, dopamine selectively inhibits the vascular permeability and angiogenic activity of vascular endothelial growth factor (VPF/VEGF). The bioavailability of dopamine is regulated by dopamine receptors D2 (DRD2), D4 (DRD4) and dopamine transporter 1 (DAT1/SLC6A3) genes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0169-5002
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
56
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
17-23
|
|
pubmed:meshHeading |
pubmed-meshheading:17175058-Aged,
pubmed-meshheading:17175058-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:17175058-Case-Control Studies,
pubmed-meshheading:17175058-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:17175058-Female,
pubmed-meshheading:17175058-Genotype,
pubmed-meshheading:17175058-Humans,
pubmed-meshheading:17175058-Logistic Models,
pubmed-meshheading:17175058-Lung Neoplasms,
pubmed-meshheading:17175058-Male,
pubmed-meshheading:17175058-Middle Aged,
pubmed-meshheading:17175058-Polymorphism, Single Nucleotide,
pubmed-meshheading:17175058-Receptors, Dopamine,
pubmed-meshheading:17175058-Risk,
pubmed-meshheading:17175058-Smoking
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer.
|
|
pubmed:affiliation |
International Agency for Research on Cancer, Lyon, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
